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Of note, the mevalonate pathway is equally responsible for the synthesis of coenzyme Q10 (CoQ10), the reduced form of which (ubiquinol) is generated by FSP1 and was recently shown to act as a radical trapping agent preventing ferroptosis 55,56

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In pH 7.4 phosphate buffer, 1c (present in the keto and hydrate forms) hydrolysed to -ketoester 1d , also in the keto and hydrate forms